免费论文下载中心 3.2 气体吸入麻醉药 N2O和氙气与挥发性吸入麻醉药物的麻醉机制可能不同，它们都能抑制NMDA受体功能［20］;同时也能够明显抑制爪蟾卵母细胞表达的大鼠nnAChRs功能。Suzuki等［21］使用双电极电压钳制技术研究N2O和氙气对非洲爪蟾卵母细胞中nnAChRs (α7)5亚型表达的影响，发现在临床麻醉剂量时N2O和氙气以浓度依赖性的方式可逆性地抑制(α7)5亚型，而且其抑制效应是非竞争性和非电压依赖性的。
　　4 结 语
　　目前大量研究证实nnAChRs具有十分广泛的作用，通过电生理的、药理的以及行为学等方面的研究证明nnAChRs在吸入麻醉药镇痛作用方面起到重要的作用。随着研究技术的不断进步，将会进一步明确nnAChRs的特性及其功能，相信在不久的将来，人们对nnAChRs及其与吸入麻醉药镇痛作用关系的研究必将迈上一个新台阶。
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